Tumor Susceptibility Gene 101 (TSG101) Peptide
TSG101
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN985664
Aperçu rapide pour Tumor Susceptibility Gene 101 (TSG101) Peptide (ABIN985664)
Antigène
TSG101
(Tumor Susceptibility Gene 101 (TSG101))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TSG101 antibody (Catalog #: ARP38773_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
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Sujet
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TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. TSG101 contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. TSG101 may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of TSG101 appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in TSG101 gene occur in high frequency in breast cancer. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Alias Symbols: TSG10, VPS23
Protein Interaction Partner: HGS,HGS,JEVgp1,PDCD6IP,PDCD6IP,TSG101,TSG101,VPS28,VPS28,VPS28,VPS37A,VPS37B,gag,AATF,AR,CDKN1A,CEP55,DAXX,DMAP1,DNMT1,EP300,GGA1,GGA3,GMCL1,HCK,HGS,KRT15,LRSAM1,MDM2,NR3C1,PDCD6IP,PPFIBP2,SNF8,TOM1L1,TP53,UBA52,VPS28,VPS36,VPS37A,VPS37B,VPS37C,VPS37D,AR,CDKN1A,CEP55,DMAP1,EP300,GGA3,HGS,ITSN1,KIF5A,KRT15,LRSAM1,MDM2,NR3C1,PPFIBP2,SCAMP3,SCNN1A,THRB,TP53,UBC,VPS28,VPS37A,VPS37B,VPS37C
Protein Size: 390 -
Poids moléculaire
- 44 kDa
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ID gène
- 7251
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NCBI Accession
- NM_006292, NP_006283
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UniProt
- Q99816
Antigène
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